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أضخم موقع علمي صحي موثق في العالم لسعادة العائلة وصحتها, بالعلم والإيمان نبني الميزان

90602220

ab- PROTECTIVE EFFECTS OF BOVINE COLOSTRUM ON BRAIN ISCHEMIA/RE-PERFUSION INJURY IN RAT

ab- PROTECTIVE EFFECTS OF BOVINE COLOSTRUM ON BRAIN ISCHEMIA/RE-PERFUSION INJURY IN RAT










No. Divisions/Titles for AbstractDetails



1Abstract TitlePROTECTIVE EFFECTS OF BOVINE COLOSTRUM ON BRAIN ISCHEMIA/REPERFUSION INJURY IN RAT


2Abstract SourceClinical Nutrition Supplements, 3, 42.


3Abstract Author(s)Choi, H. & Ko, Y.


4Article AffiliationEmergency Department, Kyung Hee University Hospital, Seoul, South Korea


5Abstract















Rationale: The authors reported previously that bovine colostrum (BC) reduced the serum pro-inflammatory cytokines and ROS levels in intestinal ischemia/reperfusion injured rats. The pro-inflammatory cytokines and ROS are thought to play an important role in the aggravation of the ischemic brain injury following brain ischemia and reperfusion. So the aim of our study is to investigate the brain protective effects of BC in brain ischemia/ reperfusion (I/R) injured rats. Methods: In male rats middle cerebral artery occlusion (1.5h) and subsequent reperfusion (72h) (MCAO/R) was induced with the filament model. After 1-hours reperfusion and twice daily during the experiment, the experimental group was given BC (4 ml/kg/day) per oral route (PO) and the other groups received 0.9% saline and low fat milk (LFM). Seventy-two hours later, we assessed the infarct volume using a computerized image analysis system, serum levels of pro-inflammatory cytokines (IL-1b, IL-6, and TNF-a), and oxidative stress (MDA). Results: The infarct sizes showed a significant reduced in rats with BC feeding after I/R when compared to rats with LFM/saline feeding. IL-1b, IL-6, and TNF-a serum levels were significantly reduced in rats with BC feeding when compared to rats with LFM/saline feeding (p < 0.05). MDA level of brain tissue was significantly reduced in rats with BC feeding when compared to rats with LFM/saline feeding (p < 0.05). Conclusion: BC may have beneficial effects in preventing brain I/R injury. BC ingestion after reperfusion in the patients with cerebral infarction may promote the recovery of brain I/R injury.


6Summary




The authors reported previously that bovine colostrum (BC) reduced the serum pro-inflammatory cytokines and ROS levels in intestinal ischemia/reperfusion injured rats. The pro-inflammatory cytokines and ROS are thought to play an important role in the aggravation of the ischemic brain injury following brain ischemia and reperfusion. The infarct sizes showed a significant reduced in rats with BC feeding after I/R when compared to rats with LFM/saline feeding. BC may have beneficial effects in preventing


7Article Published Date8 September 2008.


8
Study TypeInvivo


9
SubstancesBovine colostrum


10
DiseasesBrain ischemic/ reperfusion injury.


11Pharmacological Actionsneuroprotective-protect brain from injury/infarction.

12
Linkhttps://goo.gl/MzXWqY








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